Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), FITC

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1 µg/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA5-28729)
• APC (MA5-28718)
• Biotin (MA5-28720)
• Cyanine5 (MA5-28722)
• PE (MA5-28726)
• PE-Cyanine5 (MA5-28727)
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, playing a key role in T cell signal transduction, differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
CD8α is critical for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes recruits Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are essential for pathogen and tumor clearance. Differentiation of naïve CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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