Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), FITC
닭 CD8α 항원을 인식하는 단클론 항체로, FITC 형광 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 마우스 IgG1, kappa 아이소타입이며, 고순도 정제 형태로 제공됩니다. PBS 완충용액에 0.1% 이하 아지드 포함, 4°C 암소 보관.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-8 |
| Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745683 |
Additional Formats
- Unconjugated (MA5-28729)
- APC (MA5-28718)
- Biotin (MA5-28720)
- Cyanine5 (MA5-28722)
- PE (MA5-28726)
- PE-Cyanine5 (MA5-28727)
- Custom conjugation available upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, playing a key role in T cell signal transduction, differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
CD8α is critical for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes recruits Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are essential for pathogen and tumor clearance. Differentiation of naïve CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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