Thermo Fisher Scientific c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Epitope sequence: EQKLISEEDL, located in amino acids 410–419 of human c-Myc protein.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK has been associated with regulation of cell proliferation and cycle control. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-Myc oncogene (p62 c-Myc) regulates normal cellular proliferation and differentiation. Deregulated expression can induce apoptosis in multiple cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags at amino- or carboxy-termini of target proteins.

c-Myc-, N-Myc-, and L-Myc-encoded proteins function in proliferation, differentiation, and neoplastic transformation. Amplification of the c-Myc gene has been observed in human tumors such as lung, breast, and colon carcinomas, while N-Myc amplification occurs in neuroblastomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders.

Aberrant expression of c-Myc has been reported in tumors from various origins, including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, prostatic, thyroid, nasopharyngeal, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.