Thermo Fisher Scientific c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)
c-Myc 단백질을 인식하는 인간 재조합 단일클론 항체(클론 9E10)로, Western blot, IHC, ICC, IP 등 다양한 응용에 적합합니다. HEK293 세포에서 발현되었으며, 액상 형태로 제공되고 4°C에서 보관 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | A synthetic peptide corresponding to aa 408–439 from C-terminus of human c-Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-Myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.
Deregulated expression of c-Myc induces apoptosis and contributes to oncogenesis in multiple tissues including lung, breast, colon, gastric, hepatic, ovarian, and hematopoietic systems. Amplification or translocation of the c-Myc gene is observed in cancers such as Burkitt’s lymphoma and other B-cell proliferative disorders.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing the Myc epitope tag fused to either amino- or carboxy-termini of target proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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