Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)
Thermo Fisher Scientific의 c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)은 인간 c-Myc 단백질을 인식하는 재조합 단일클론 항체입니다. Western blot, IHC, ICC, IP 등 다양한 분석에 사용 가능하며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / F(ab)₂, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide (aa 408–439, C-terminus of human c-Myc) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in amino acids 410–419 of human c-Myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in tumor cells and is crucial for cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK has been linked to regulation of cell proliferation and cycle control. c-Myc plays essential roles in vasculogenesis and angiogenesis during tumor development.
Antibodies against c-Myc epitopes can detect Myc-tagged proteins fused to either amino- or carboxy-termini. Amplification or translocation of the c-Myc gene is associated with various cancers, including:
- Lung, breast, and colon carcinomas
- Neuroblastomas (N-Myc amplification)
- Burkitt’s lymphoma and other B-cell lymphoproliferative diseases
- Tumors of colorectal, gastric, hepatic, ovarian, and hematopoietic origin
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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