Thermo Fisher Scientific c-Myc Chimeric Recombinant Human Monoclonal Antibody (9E10)
Thermo Fisher Scientific의 c-Myc 키메라 재조합 인간 단클론 항체(9E10)는 Western blot, IHC, ICC, IP 등 다양한 어플리케이션에 적합합니다. 인간 IgG3 기반으로 HEK293 세포에서 발현되며, c-Myc 단백질의 410–419 아미노산 서열(EQKLISEEDL)을 인식합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG3, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | A synthetic peptide corresponding to aa 408–439 from C-terminus of human c-Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-Myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK has been linked to cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.
The c-myc oncogene (p62 c-myc) regulates normal cell proliferation and differentiation. Deregulated expression can induce apoptosis in multiple cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to target proteins.
Amplification of the c-Myc gene has been observed in human tumors, including lung, breast, and colon carcinomas, while N-Myc amplification is associated with neuroblastomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant c-Myc expression is found in diverse tumors such as colorectal, gastric, hepatic, mammary, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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