Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)
Thermo Fisher Scientific의 c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)는 인간 c-Myc 단백질을 인식하는 재조합 단일클론 항체로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. 고순도 Protein A 정제 제품으로 연구용으로만 사용됩니다.
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Thermo Fisher Scientific c-Myc Chimeric Recombinant Mouse Monoclonal Antibody (9E10)
Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide corresponding to aa 408–439 from C-terminus of human c-myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation of c-Myc at Thr58/Ser62 by enzymes such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with cell proliferation and cycle regulation. Studies indicate c-Myc is essential for vasculogenesis and angiogenesis during tumor development.
The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation. Deregulated expression can induce apoptosis in multiple cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino or carboxy termini of target proteins.
c-Myc-, N-Myc-, and L-Myc-encoded proteins are involved in cell proliferation and neoplastic diseases. Amplification of the c-Myc gene is found in human tumors such as lung, breast, and colon carcinomas, while N-Myc amplification is common in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions.
Aberrant expression of the c-myc gene occurs in tumors of diverse origins including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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