Thermo Fisher Scientific Phospho-Tau (Ser356) Polyclonal Antibody
Phospho-Tau (Ser356) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. Alzheimer’s 질환 연구 등 Tau 단백질 인산화 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Tau that contains serine 356. The sequence is conserved in many species including mouse, rat, rhesus monkey, baboon, cow and goat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533744 |
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between them.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), a major component of neurofibrillary lesions in Alzheimer’s disease (AD) brain.
Phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration.
Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is also associated with other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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