Thermo Fisher Scientific Phospho-Tau (Ser214) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting Tau functions as a linker between both structures.

Axonal polarity is determined by Tau/MAPT localization in the neuronal cell body domain defined by the centrosome. Short Tau isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs Tau’s microtubule binding, leading to microtubule destabilization and neuronal degeneration in AD. Phosphorylation is mediated by kinases such as GSK-3β, PKA, CDK5, and casein kinase II. Hyper-phosphorylated Tau is also found in other neurodegenerative diseases including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.