Thermo Fisher Scientific Mek6 Polyclonal Antibody
Rabbit polyclonal antibody against human Mek6 for WB and IHC applications. Reacts with human, mouse, and rat samples. High specificity and sensitivity, purified by antigen affinity chromatography. Suitable for research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from internal segment of human Mek6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: 3T3 cells
- Cellular location: localizes to nucleus, cytoplasm, and cytoskeleton
Target Information
MKK6 (MEK6, MAP2K6) is a member of the dual specificity protein kinase family, functioning as a mitogen-activated protein (MAP) kinase kinase. MAP kinases act as integration points for multiple biochemical signals. MKK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress.
As a key component of the p38 MAP kinase-mediated signaling pathway, MKK6 is involved in stress-induced cell cycle arrest, transcription activation, and apoptosis.
Tissue specificity: Isoform 2 is expressed only in skeletal muscle, while Isoform 1 is found in skeletal muscle, heart, and to a lesser extent in liver or pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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