Thermo Fisher Scientific Mekk-1 Polyclonal Antibody
MEKK-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.01% sodium azide 포함. 세포질 내 발현 단백질 검출용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from internal segment of human Mekk-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human uterine carcinoma, thyroid carcinoma
- Cellular location: Cytoplasmic
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells.
MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2), leading to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade.
The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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