Thermo Fisher Scientific Phospho-Tau (Thr181) Recombinant Rabbit Monoclonal Antibody (5H9L11)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:5,000
• View 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:10–1:100
• View publications

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone antibody DNA sequences from immunoreactive rabbits and screen individual clones for optimal production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to rabbit immune repertoire

Target Information

Tau is a neuronal microtubule-associated protein primarily localized on axons. It promotes tubulin polymerization and stabilizes microtubules.

• The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, acting as a linker protein.
• Hyper-phosphorylated Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease brains.
• Phosphorylation impairs Tau’s microtubule-binding ability, leading to destabilization and neuronal degeneration.
• Kinases involved in Tau phosphorylation include GSK-3β, PKA, CDK5, and casein kinase II.
• Abnormal Tau phosphorylation is associated with Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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