ELK Biotechnology Chk2 rabbit pAb
Chk2 rabbit pAb는 인간, 마우스, 랫트 시료에서 사용 가능한 폴리클로날 항체로, DNA 손상 반응 및 세포주기 조절 연구에 적합합니다. WB, IHC, IF, ELISA 등에 활용 가능하며, 고순도 IgG 형태로 -20°C 보관 시 1년 안정적입니다.
- 판매단위
- pk
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제품명
Chk2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHEK2 (AA range: 35–84) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 61 kD |
| Gene ID (Human) | 11200 |
| Human Swiss-Prot No. | O96017 |
| Cellular Localization | [Isoform 2]: Nucleus Isoform 10: Present throughout the cell [Isoform 4]: Nucleus [Isoform 7]: Nucleus [Isoform 9]: Nucleus [Isoform 12]: Nucleus Nucleus, PML body; Nucleus, nucleoplasm; Recruited into PML bodies together with TP53 |
| Species Reactivity | Human; Mouse; Rat |
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein inhibits CDC25C phosphatase, preventing entry into mitosis, and stabilizes the tumor suppressor protein p53, leading to cell cycle arrest in G1. Additionally, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype associated with inherited mutations.
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