Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), FITC, eBioscience
CD49f (Integrin alpha 6) 단백질을 인식하는 eBioGoH3 단클론 항체로, FITC 형광 표지형입니다. 인간 및 마우스 반응성이 있으며, Flow Cytometry에 최적화되어 있습니다. 세포 부착 및 신호전달 연구용으로 적합하며, 0.25 µg/test 권장 사용량입니다.
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Thermo Fisher Scientific CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), FITC, eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | View 48 publications |
| Neutralization (Neu) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioGoH3 (GoH3) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11149121 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
The eBioGoH3 monoclonal antibody reacts with mouse and human CD49f, also known as integrin alpha 6, VLA-6 alpha chain, and platelet gpIc. CD49f is a 120 kD transmembrane protein that associates with CD29 (integrin beta 1) to form the VLA-6 complex, and with CD104 (integrin beta 4) to form the alpha 6 beta 4 complex.
CD49f is expressed primarily on T cells, monocytes, platelets, epithelial and endothelial cells, and germinal center B cells. The antibody is cross-reactive with integrin alpha 6 on human, mouse, and bovine cells, and can block the binding of integrin alpha 6 to laminin.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of normal human peripheral blood cells at ≤0.25 µg/test.
A test is defined as the amount of antibody staining a cell sample in 100 µL final volume. Recommended titration for optimal performance.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD49f (Integrin alpha-6, ITGA6) encodes the integrin alpha chain alpha 6 protein. Integrins are cell-surface proteins composed of alpha and beta chains that form various integrin complexes (e.g., alpha6/beta4 = TSP180, alpha6/beta1 = VLA-6).
They participate in cell adhesion and signaling, mediating interactions between the extracellular matrix (ECM) and intracellular cytoskeletal linker proteins. These signals regulate cell shape, mobility, proliferation, and survival.
CD49f is predominantly expressed by epithelial cells and plays a structural role in hemidesmosomes. Over 18 alpha and 8 beta subunits with multiple splice variants have been identified in mammals. Certain integrins also bind soluble ligands or counter-receptors such as ICAMs, promoting cell aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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