Thermo Fisher Scientific ABL1/ABL2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ABL1/2.

Target Information

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl is a protein with tyrosine kinase activity and an SH2 domain.
The Abl oncogene is implicated in several human leukemias including:

• 90–95% of chronic myelocytic leukemia (CML)
• 20–25% of adult acute lymphoblastic leukemia (ALL)
• 2–5% of pediatric ALL

In these leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.