Thermo Fisher Scientific ABL1/ABL2 Polyclonal Antibody
Rabbit 유래의 Polyclonal ABL1/ABL2 항체로 Western blot에 적합. 인간 ABL1 유래 펩타이드로 면역화됨. 내인성 ABL1/2 단백질 검출 가능. -20°C에서 보관하며 연구용으로만 사용.
- 카탈로그번호
- PA5106243
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABL1 (Accession P00519), corresponding to amino acid residues E44–N94 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817634 |
Product Specific Information
Antibody detects endogenous levels of total ABL1/2.
Target Information
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl is a protein with tyrosine kinase activity and an SH2 domain.
The Abl oncogene is implicated in several human leukemias including:
- 90–95% of chronic myelocytic leukemia (CML)
- 20–25% of adult acute lymphoblastic leukemia (ALL)
- 2–5% of pediatric ALL
In these leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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