Thermo Fisher Scientific AHNAK Polyclonal Antibody
AHNAK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응함. WB(1:500–1:2,000), ICC/IF(1:100)에 적합. Affinity chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AHNAK (Accession Q09666), corresponding to amino acid residues E5758–L5808 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853934 |
Product Specific Information
Antibody detects endogenous levels of total Desmoyokin.
Target Information
AHNAK1 (Desmoyokin) is a large (~700 kDa) scaffold protein that translocates to the plasma membrane after an increase of extracellular calcium level or upon protein kinase C activation and regulates extracellular calcium influx mediated by L-type Ca²⁺ channels.
AHNAK1 has been implicated in diverse signal transduction processes affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts, AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies, and is thus involved in organization of the plasma membrane architecture.
In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of non-epithelial origin AHNAK1 is predominantly nuclear; it has weak DNA-binding activity and associates with the DNA-ligase IV–XRCC4 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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