Thermo Fisher Scientific AHNAK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Desmoyokin.

Target Information

AHNAK1 (Desmoyokin) is a large (~700 kDa) scaffold protein that translocates to the plasma membrane after an increase of extracellular calcium level or upon protein kinase C activation and regulates extracellular calcium influx mediated by L-type Ca²⁺ channels.
AHNAK1 has been implicated in diverse signal transduction processes affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts, AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies, and is thus involved in organization of the plasma membrane architecture.
In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of non-epithelial origin AHNAK1 is predominantly nuclear; it has weak DNA-binding activity and associates with the DNA-ligase IV–XRCC4 complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.