Thermo Fisher Scientific DYRK2/DYRK4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DYRK2/DYRK4. Validated for Western blot at 1:500–1:2,000 dilution. Detects endogenous DYRK2/4 levels. Supplied in PBS with 50% glycerol, stored at -20°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DYRK2 (Accession Q92630), corresponding to amino acid residues G360–C410 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817636 |
Product Specific Information
This antibody detects endogenous levels of total DYRK2/4.
Target Information
DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, involved in cellular proliferation and apoptosis. Under normal conditions, nuclear DYRK2 is ubiquitinated by MDM2, leading to degradation. Upon genotoxic stress, ATM phosphorylates DYRK2, causing its dissociation from MDM2 and subsequent phosphorylation of p53, inducing apoptosis. DYRK2 may also act as a scaffold facilitating E3 ubiquitin ligase assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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