Thermo Fisher Scientific CDK7 Recombinant Rabbit Monoclonal Antibody (JJ203-01)
CDK7 단백질을 인식하는 토끼 유래 재조합 단일클론 항체. Western blot, IHC, ICC/IF, 유세포분석에 적합. 높은 특이성과 재현성을 제공하며, 동물 성분이 없는 포뮬레이션으로 일관된 결과를 지원. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ203-01 |
| Immunogen | Recombinant protein within Human CDK7 (aa 151–346) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809712 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in cell systems such as HEK293. Individual clones are screened to select optimal candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
CDK7 forms a trimeric complex with cyclin H and MNAT1, functioning as a Cdk-activating kinase (CAK). This complex is an essential component of the transcription factor TFIIH, involved in transcription initiation and DNA repair. It serves as a link between transcription regulation and the cell cycle. The bound complex contributes to double-strand break repair associated with BRCA1 function. CDK7 may be a target of germline cancer-inducing mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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