Thermo Fisher Scientific TPCN2 (extracellular) Polyclonal Antibody
Rabbit 폴리클로날 항체로 TPCN2 단백질의 extracellular 영역을 인식. Western blot 및 동결 조직 면역염색에 사용 가능. Lyophilized 형태로 공급되며 -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide KKTLKSIRW(S)LPE(C), corresponding to amino acid residues 187–199 of mouse Two pore calcium channel protein 2 with replacement of amino acid 192 with serine (S) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.85 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736722 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane.
Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain.
The Tpcn2 protein localizes to lysosomal membranes and enables NAADP-induced calcium ion release from lysosome-related stores.
Tpcn2 is ubiquitously expressed, with elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation.
Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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