Thermo Fisher Scientific TPCN2 (extracellular) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

-

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide KKTLKSIRW(S)LPE(C), corresponding to amino acid residues 187-199 of mouse Two pore calcium channel protein 2 with replacement of amino acid 192 with serine (S) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TPCN2,uniProtId:Q8BWC0-1,ncbiNodeId:10090,antigenRange:187-199,antigenLength:731,antigenImageFileName:PA5-77336_TPCN2_Q8BWC0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-77336_TPCN2_Q8BWC0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2736722

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.

Target Information

Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.