Thermo Fisher Scientific TMEM66 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide (C)ELGLSKLKESGKHQS, corresponding to amino acid residues 141-155 of rat SOCE-associated regulatory factor if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM66,uniProtId:Q6AYN2-1,ncbiNodeId:10114,antigenRange:141-155,antigenLength:334,antigenImageFileName:PA5-77334_TMEM66_Q6AYN2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-77334_TMEM66_Q6AYN2-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2736711

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.

Target Information

Saraf encodes a protein that is a negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the de-oligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.