Thermo Fisher Scientific Hepatitis B Virus Core Antigen Monoclonal Antibody (10C6)

Thermo Fisher Scientific Hepatitis B Virus Core Antigen Monoclonal Antibody (10C6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody can be used for ELISA, Western blot, IHC, and Immunoprecipitation of in vitro-translated core and pre-core proteins. It strongly recognizes WHc (but not DHBc) in ELISA and immunoblot, and reacts with synthetic HBc peptides.
Epitope: amino acids 138–145.

Target Information

Hepatitis B virus (HBV) is a major cause of acute and chronic liver disease and the most common form of parenterally transmitted viral hepatitis. HBV is spherical, approximately 42 nm in diameter, and contains a 27 nm partially double-stranded DNA core within a lipoprotein envelope.
The nucleocapsid core antigen is designated as hepatitis B core antigen (HBcAg), while the outer surface antigens are hepatitis B surface antigens (HBsAg). Core antigens are localized in the nuclei, and surface antigens are found in the cytoplasm of infected cells.
Antibodies to surface antigens appear early in infection, whereas antibodies to core antigens are detected later. Approximately 350–400 million people worldwide are HBV carriers, making HBV one of the most common human pathogens.
Immunization against hepatitis B is an important preventive measure and is offered to children in many countries. Persistent HBV infection can lead to hepatocellular carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.