Thermo Fisher Scientific CD49f Monoclonal Antibody (Go H3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-91026 detects Integrin alpha 6 from mouse and human samples.

Target Information

CD49f (Integrin alpha-6, ITGA6) is the integrin alpha chain α6 protein. Integrins are integral cell-surface proteins composed of an alpha and a beta chain. Each alpha chain may combine with multiple beta partners, forming different integrins. For example, α6 may combine with β4 to form integrin TSP180 or with β1 to form integrin VLA-6.

Integrins participate in cell adhesion and cell-surface-mediated signaling. Two transcript variants encoding different isoforms have been identified for CD49f. Functionally, integrins act as cell surface receptors interacting with the extracellular matrix (ECM) and mediating intracellular signals that influence cell shape, mobility, and cell cycle progression.

Integrin receptors form structural and functional linkages between the ECM and cytoskeletal linker proteins. Signaling mediated by integrin–ECM interactions integrates with growth factor signaling to regulate proliferation, cytoskeletal reorganization, and cellular survival responses. CD49f is predominantly expressed by epithelial cells and plays a crucial structural role in hemidesmosomes. Over 18 alpha and 8 beta subunits with numerous splice variants have been identified in mammals. Some integrins can also bind to soluble ligands or counter-receptors on adjacent cells, such as intracellular adhesion molecules (ICAMs), promoting cell aggregation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.