Thermo Fisher Scientific CD11b Polyclonal Antibody
Thermo Fisher Scientific CD11b Polyclonal Antibody는 인간 CD11b 단백질을 인식하는 Rabbit IgG 기반 항체로, Western blot 및 IHC(Paraffin)에 적합합니다. 세포막 위치 검출에 활용되며, 면역접착 및 세포 간 상호작용 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encoding aa 936–1154 of human CD11b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Jurkat cell lysate
- Cellular location: Cell membrane
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- NK cell subsets
- Dendritic cell subsets
- Microglia in the brain
Functions as receptor for:
- ICAM-1 (CD54)
- ICAM-2 (CD102)
- ICAM-4 (CD242)
- CD14
- CD50
- CD23
- Heparin
- iC3b
- Fibrinogen
- Factor X
These interactions are critical for cell-cell and cell-matrix adhesion. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. Expression increases during monocyte maturation and varies among tissue macrophages.
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to lupus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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