Thermo Fisher Scientific ALK/p80 Polyclonal Antibody
인간 ALK 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 2–10 µg/mL 농도로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 뇌 발달 및 종양 연구용으로 적합. 4°C 단기, -20°C 장기 보관 권장.
- 카탈로그번호
- 500-1094
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to a region spanning the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human anaplastic lymphoma
- Cellular location: Nuclear
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been identified in various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement involving ALK and the nucleophosmin (NPM) gene results in the oncogenic NPM-ALK fusion gene.
ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It is essential for neuronal development and signaling in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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