Thermo Fisher Scientific CD72 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CD72 protein. Validated for Western blot applications. Supplied as a liquid, unconjugated form with 0.5 mg/mL concentration. Suitable for detecting CD72 in B cells and antigen-presenting cells. For research us...
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Applications and Tested Dilution
- Western Blot (WB): 0.1–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of human CD72 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Tonsil
- Cellular Location: Cell membrane
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer, primarily in B cells and other antigen-presenting cells such as dendritic cells and macrophages. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1 to suppress B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72, resulting in dissociation of SHP-1 and enabling B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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