Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Neat

Product Specifications

Additional Formats

• Unconjugated (Cat. MA5-16982)
• APC (Cat. MA5-16980)
• Custom conjugation available upon request

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Target Information

CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, involved in signal transduction and receptor regulation.
CD33 is expressed on myelomonocytic lineage cells, binds sialic acid residues on N- and O-glycans, and serves as a therapeutic target for acute myeloid leukemia (AML). It is present on granulocyte and macrophage precursors in bone marrow but absent on pluripotent stem cells. CD33 is also a useful marker for peripheral monocytes and for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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