Thermo Fisher Scientific Human SHISA3 Synthetic Peptide
Human SHISA3 단백질의 중심부 15개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. Western blot 차단용으로 사용 가능하며, PA5-34527 항체와 함께 사용 시 효과적입니다. 인간 특이적 반응성을 가지며, PBS 용액 형태로 제공됩니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human SHISA3.
PEP-1570 can be used as a blocking peptide with polyclonal antibody PA5-34527.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by attenuation of both FGF and WNT signaling.
The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region.
Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling.
Shisa physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibits their posttranslational maturation and trafficking to the cell surface.
Loss of Shisa function sensitizes the neuroectoderm to Wnt signaling and suppresses head formation during gastrulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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