Thermo Fisher Scientific H3K27ac Monoclonal Antibody (GT261)
H3K27ac 단백질의 아세틸화된 형태를 인식하는 단클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, Protein G로 정제된 액상 형태입니다. 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT261 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Histone H3K27ac (acetyl Lys27) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787183 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%).
- Positive Control: HeLa, HeLa (0.4 µM Trichostatin A treatment for 18 hr).
- Centrifuge briefly prior to opening the vial.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3, along with four core histone proteins, binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Post-translationally, histones are modified in various ways to change chromatin structure or allow binding of specific transcription factors. The N-terminal tail of histone H3 can undergo several modifications such as methylation, acetylation, and phosphorylation, influencing multiple cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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