Thermo Fisher Scientific TRPM4 Monoclonal Antibody (OTI14C3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TRPM4 is a calcium-activated, non-selective (CAN) cation channel that mediates membrane depolarization.
While activated by increased intracellular Ca²⁺, it remains impermeable to Ca²⁺ itself. It transports monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization.
It plays a key role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, and cochlear hair cells.
TRPM4 participates in T-cell activation by modulating Ca²⁺ oscillations required for NFAT-dependent IL2 production and contributes to myogenic constriction of cerebral arteries.
It also regulates insulin secretion in pancreatic β-cells and may influence pacemaking or irregular electrical activity under Ca²⁺ overload.
Additionally, it affects T-helper cell motility and cytokine production via calcium signaling and NFATC1 localization, enhancing cell proliferation through β-catenin signaling upregulation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.