Thermo Fisher Scientific Phospho-EZH2 (Ser474) Polyclonal Antibody
EZH2 단백질의 Ser474 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot에 적합하며 인간과 랫트 시료에서 반응. 고순도 정제 및 안정한 PBS/glycerol buffer로 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EZH2 (Accession Q15910), corresponding to amino acid residues around phosphorylated Ser474 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817621 |
Product Specific Information
Phospho-EZH2 (Ser474) Antibody detects endogenous levels of EZH2 only when phosphorylated at S474.
Target Information
EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes that maintain transcriptional repression across cell generations.
This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in hematopoietic and central nervous system function.
Mutations affecting EZH2 can cause Weaver syndrome (WVS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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