Thermo Fisher Scientific Phospho-DEPDC5 (Thr1531) Polyclonal Antibody
DEPDC5 단백질의 Thr1531 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, 1:1,000~1:3,000 희석 비율로 사용 가능. PBS/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용 전용 시약.
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- PA5106226
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DEPDC5 (Accession O75140), corresponding to amino acid residues around phosphorylated Ser1530 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817624 |
Product Specific Information
Antibody detects endogenous levels of DEPDC5 only when phosphorylated at T1531.
Target Information
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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