Thermo Fisher Scientific CD41a Monoclonal Antibody (HIP8), APC, eBioscience
인간 CD41a(Integrin αIIb) 인식하는 HIP8 단클론 항체로, APC 형광 표지되어 있습니다. 혈소판 및 거핵세포 분석용으로 Flow Cytometry에 최적화되어 있으며, 5 µL/test로 사전 적정된 고품질 항체입니다.
- 카탈로그번호
- 17-0419-42
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Thermo Fisher Scientific CD41a Monoclonal Antibody (HIP8), APC, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | View 6 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIP8 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573144 |
Additional Formats Available
- Unconjugated
- APC-eFluor 780
- eFluor 450
- FITC
- NovaFluor Blue 510
- NovaFluor Blue 585
- NovaFluor Blue 660-120S
- NovaFluor Yellow 590
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Custom conjugation available upon request
Product Specific Information
The HIP8 monoclonal antibody reacts with human CD41 molecule (integrin alpha IIb, platelet GPIIb). CD41 associates with integrin beta3 (CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex serves as a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin, and thrombospondin, mediating platelet aggregation. HIP8 blocks platelet aggregation.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated for flow cytometry of human platelets; 5 µL (0.125 µg) per test.
A test is defined as the antibody amount that stains a cell sample in 100 µL volume. Cell number may range from 10⁵ to 10⁸ cells/test.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa α and 23 kDa β) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 mediates platelet aggregation and binds von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury. It is mainly expressed in megakaryocyte-platelet lineage and appears during early hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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