Thermo Fisher Scientific CD42b Monoclonal Antibody (HIP1), APC, eBioscience
인간 CD42b 단백질을 인식하는 HIP1 단클론 항체로, APC로 결합되어 유세포분석(Flow Cytometry)에 최적화되어 있습니다. 혈소판 활성화 및 응고 관련 연구에 적합하며, 4°C에서 암소 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | View 4 publications |
| Functional Assay (Functional) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIP1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573146 |
Available Formats
- Unconjugated
- FITC
- NovaFluor Blue 510
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Yellow 610
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
Description:
The HIP1 monoclonal antibody reacts with the human CD42b molecule, a 135 kDa transmembrane protein also known as platelet gpIb.
Applications Reported:
This HIP1 antibody has been reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of human platelets.
Recommended usage: 5 µL (0.5 µg) per test (defined as staining a sample in 100 µL volume).
Cell number range: 10⁵–10⁸ cells/test (empirical determination required).
Excitation/Emission: 633–647 nm / 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD42b is a platelet activation marker involved in coagulation and platelet aggregation. It interacts with extracellular matrix and adhesion molecules, and its expression is regulated by VEGF and PDGF.
CD42b forms part of the GPIb-IX-V receptor complex, essential for platelet-rich thrombus formation by binding to von Willebrand factor (VWF) at vascular injury sites. It also binds thrombin, coagulation factors XI/XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin.
The extracellular domain contributes to metastasis. CD42b is expressed on platelets and megakaryocytes in bone marrow. Mutations and polymorphisms in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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