Thermo Fisher Scientific PLA2R1 Monoclonal Antibody (CL0474)
PLA2R1 단백질을 인식하는 마우스 단클론 항체(CL0474)로, Western blot, IHC, ICC/IF에 적합합니다. Human 시료에 반응하며, Protein A로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20,000–1:50,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0474 |
| Immunogen | Recombinant protein corresponding to Human PLA2R1 (amino acids 395–530, length 1463) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637222 |
Product Specific Information
Immunogen sequence:
EEKTWHEALR SCQADNSALI DITSLAEVEF LVTLLGDENA SETWIGLSSN KIPVSFEWSN DSSVIFTNWH TLEPHIFPNR SQLCVSAEQS EGHWKVKNCE ERLFYICKKA GHVLSDAESG CQEGWERHGG FCYKID
- Highest antigen sequence identity to the following orthologs:
- Mouse: 74%
- Rat: 76%
- Binds to an epitope located within the peptide sequence KIPVSFEWSN, as determined by overlapping synthetic peptides.
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also binds to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2.
Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as:
- Activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation
- Production of lipid mediators
- Selective release of arachidonic acid in bone marrow-derived mast cells
- In neutrophils, activation of p38 MAPK to stimulate elastase release and cell adhesion
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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