Thermo Fisher Scientific SLC22A2 Monoclonal Antibody (CL0628)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

• Immunogen sequence:
  ESPRWLISQN KNAEAMRIIK HIAKKNGKSL PASLQRLRLE EETGKKLNPS FLDLVRTPQI R
• Epitope: Binds to an epitope within the peptide sequence KNAEAMRIIKHIAKK as determined by overlapping synthetic peptides.
• Ortholog identity: Mouse - 84%, Rat - 77%.

Target Information

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from various tissues and play roles in eliminating endogenous amines, cationic drugs, and other xenobiotics.
OCTs have a 12-transmembrane-domain structure with a large extracellular hydrophilic loop.

• OCT1: Primarily expressed in the liver
• OCT2 (SLC22A2): Expressed in the kidney, localized to basolateral and luminal membranes of distal and proximal tubules; mediates pH-sensitive tubular uptake of organic compounds
• OCT3: Expressed in placenta, skeletal muscle, prostate, aorta, and liver
• OCT2-A: An additional splice variant of OCT2

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.