Thermo Fisher Scientific PLA2R1 Monoclonal Antibody (CL0485)
Human PLA2R1 단백질을 인식하는 mouse monoclonal antibody (Clone CL0485). Western blot과 IHC(P)에서 검증됨. Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0485 |
| Immunogen | Recombinant protein corresponding to Human PLA2R1 (amino acids 395–530, UniProt ID: Q13018-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637223 |
Product Specific Information
Immunogen sequence:
EEKTWHEALR SCQADNSALI DITSLAEVEF LVTLLGDENA SETWIGLSSN KIPVSFEWSN DSSVIFTNWH TLEPHIFPNR SQLCVSAEQS EGHWKVKNCE ERLFYICKKA GHVLSDAESG CQEGWERHGG FCYKID
Highest antigen sequence identity to the following orthologs:
- Mouse: 74%
- Rat: 76%
Binds to an epitope located within the peptide sequence VKNCEERLFYICKKA, as determined by overlapping synthetic peptides.
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also binds to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2.
Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as:
- Activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation
- Production of lipid mediators
- Selective release of arachidonic acid in bone marrow-derived mast cells
- Activation of p38 MAPK in neutrophils to stimulate elastase release and cell adhesion
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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