Thermo Fisher Scientific CD9 Monoclonal Antibody (EM-04), PE

Applications

• Flow Cytometry (Flow): 2–5 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD9 antigen, a 24 kDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes, and activated T lymphocytes.

Target Information

CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, and by neurons and glial cells in the peripheral nervous system.
CD9 belongs to the tetraspanin family, which spans the membrane four times. In pre-B cells and platelets, CD9 regulates cell activation and aggregation, possibly through association with integrin CD41/CD61 (GPIIb/GPIIIa).
CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion. It plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on dendritic cell plasma membranes, which is important for effective T-cell stimulation.
CD9 functions in differentiation, adhesion, and signal transduction, and its expression plays a critical role in suppressing cancer cell motility and metastasis. It is considered a metastasis suppressor in solid tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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