Thermo Fisher Scientific CD98 Monoclonal Antibody (MEM-108), PE

Applications

• Flow Cytometry (Flow): 20 µL / 1×10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glycosylated light chain).
CD98 is expressed on T lymphocytes (upon activation) and activated NK cells; it is also present at low levels on B lymphocytes, NK cells, monocytes, and platelets.

Target Information

CD98 (4F2) is a type II transmembrane glycoprotein that serves as the heavy chain of heterodimeric amino acid transporters (HATs).
CD98, linked to various light chains by disulfide bonds, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells.
It interacts with β1 integrins and increases their affinity for ligands.
Beyond its role in amino acid transport, CD98 is involved in cell fusion and activation, and implicated in regulation of cellular differentiation, growth, and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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