Thermo Fisher Scientific HIP1R Monoclonal Antibody (1E1)
HIP1R 단일클론 항체(1E1)는 인간, 마우스, 랫에서 반응하며 Western blot, IHC, IP에 사용 가능. 비결합형 액상 형태로 제공되며 HeLa 및 rat brain lysate에 양성 대조로 적합. 헌팅틴 질환 및 종양 연구용으로 최적화된 연구용 항체.
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Thermo Fisher Scientific HIP1R Monoclonal Antibody (1E1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Bacteria, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E1 |
| Immunogen | Human HIP1r-TALIN Homology Region (57 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2248284 |
Product Specific Information
Suggested positive control: HeLa whole cell lysate and rat brain homogenate, HeLa whole cell lysate, antigen standard for IFT57 (transient overexpression lysate), rat brain protein.
Target Information
Huntingtin disease, a neurodegenerative condition, is caused by expansion of a polymorphic glutamine tract in huntingtin. Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein potentially involved in the pathogenesis of Huntingtin disease. It plays a role in clathrin coat recruitment to lipid membranes and may contribute to tumorigenesis by promoting survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, making it a potential prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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