Thermo Fisher Scientific HIP1 Monoclonal Antibody (4B10)
HIP1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(4B10). Western blot, IHC, ICC, IP, ChIP 등 다양한 응용 가능. 인간 및 마우스 시료에 반응하며, 헌팅틴 단백질 연구 및 암 전이 관련 연구에 유용. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Immunoprecipitation (IP) | Assay-Dependent |
| ChIP assay (ChIP) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B10 |
| Immunogen | Human HIP1 (~65 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.1% Sodium Azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_568577 |
Product Specific Information
- This antibody does not react with rat samples.
- Suggested positive control: HeLa whole cell extract.
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of this disease. In addition to its role in Huntingtin disease, HIP-1 is involved in the recruitment of clathrin coats to lipid membranes and may contribute to tumorigenesis by supporting the survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, making it a potential prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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