Thermo Fisher Scientific HIP1 Monoclonal Antibody (1B11)
HIP1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간, 마우스 및 박테리아 시료에 반응합니다. Western blot, ICC/IF, IP 등 다양한 응용에 적합하며, 비결합형 액상 형태로 제공됩니다. 헌팅틴 질환 및 암 연구용으로 추천됩니다.
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Thermo Fisher Scientific HIP1 Monoclonal Antibody (1B11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bacteria, Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B11 |
| Immunogen | Human HIP1 (~65 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_568578 |
Product Specific Information
- This antibody does not react with rat samples.
- Suggested positive control: HeLa whole cell extract, HeLa whole cell lysate.
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may contribute to the pathogenesis of Huntingtin disease.
HIP-1 also plays a role in the recruitment of clathrin coats to lipid membranes and may influence tumorigenesis by promoting survival of precancerous and cancerous cells.
Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a potential prognostic factor for these cancers.
Usage Note
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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