Thermo Fisher Scientific Arginase1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1125)
Arginase1 단백질을 표적하는 인간 반응성 마우스 모노클로날 항체로, 간세포암(HCC) 마커 연구에 적합. Western blot, IHC 등 다양한 응용 가능. 고순도 Protein A/G 정제, PBS 기반 액상 형태로 안정적 보관 가능.
- 카탈로그번호
- 383-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Arginase1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1125)
Thermo Fisher Scientific Arginase1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1125)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ARG1/1125 |
| Immunogen | Recombinant human ARG1 protein fragment (around aa11–97) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification following protein degradation. By degrading arginine, Arginase 1 reduces nitric oxide production by depriving NO synthase of its substrate.
In both humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, it is found in blood neutrophils but not CCR3+ granulocytes. In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 is often expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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