Thermo Fisher Scientific CD161/KLRB1 (Killer cell lectin like receptor B1) Monoclonal Antibody (KLRB1/8910)
인간 CD161/KLRB1 단백질을 인식하는 마우스 모노클로날 항체로, IHC(P) 분석에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, PBS + BSA buffer에 보존됩니다. NK 세포 및 T 세포 연구용으로 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KLRB1/8910 |
| Immunogen | Recombinant fragment (around aa1–225) of human KLRB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human prostate, kidney, or thyroid cancer tissue
- Cellular Location: Membrane, Cytoplasm
Target Information
KLRB1 (Killer cell lectin-like receptor subfamily B, member 1, CD161) is a type II membrane protein with an external C terminus. It is expressed on nearly all NK cells and a subset of CD3⁺ T cells. This homodimeric surface protein (40–44 kDa) plays an inhibitory role in NK cell function.
Activation of KLRB1 stimulates acid sphingomyelinase/SMPD1 and increases intracellular ceramide, activating AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing T cell proliferation via anti-CD3.
KLRB1 acts as a lectin binding to Gal-α(1,3)Gal and N-acetyllactosamine epitopes, and to CLEC2D/LLT1 ligand, inhibiting NK cell-mediated cytotoxicity and IFN-γ secretion.
The protein contains extracellular C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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