Thermo Fisher Scientific KNG1/Kininogen 1 (KNG1-Heavy chain) Monoclonal Antibody (KNG1/7423)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

KNG1/7423

Immunogen

Recombinant fragment (around aa1-200) of human KNG1 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Bradykinin,uniProtId:P01042-1,ncbiNodeId:9606,antigenRange:1-200,antigenLength:644,antigenImageFileName:3827-MSM3-P0_Bradykinin_P01042-1_House_mouse.svg,antigenImageFileNamePDP:3827-MSM3-P0_Bradykinin_P01042-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control:Distinct positivity in plasma and in several cases extracellular matrix along with cytoplasmic expression in kidney.

Cellular Location: Extracellular. Secreted. Plasma.

Target Information

Kininogen-1 (KNG1), also known as BDK or bradykinin, is a protein that in humans is encoded by the KNG1 gene. It is mapped to 3q27.3. The KNG1 gene uses alternative splicing to generate two different proteins - high - molecular - weight kininogen (HMWK) and low - molecular- weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, KNG1, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. In addition to that, KNG1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.