Thermo Fisher Scientific VISTA Recombinant Mouse Monoclonal Antibody (mam82)
Recombinant mouse monoclonal antibody against VISTA (PD-1H). Suitable for IHC, ELISA, and inhibition assays. High specificity for PD-1H antigen. Purified by Protein A, supplied in PBS with ProClin 300. Ideal for cancer immunotherapy research.
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Thermo Fisher Scientific VISTA Recombinant Mouse Monoclonal Antibody (mam82)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | mam82 |
| Immunogen | The antibody was generated by immunising a PD-1H-KO mouse with mouse PD-1H Ig fusion protein and adjuvant. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074570 |
Product Specific Information
Specificity: This antibody specifically binds PD-1H.
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is encoded by the VSIR gene.
Although VISTA shares sequence homology with PD-L1, it exhibits a distinct expression pattern. In both mice and humans, VISTA is predominantly expressed on hematopoietic cells, with the highest levels on myeloid cells and lower levels on T cells. It is typically absent on B cells.
VISTA expressed by antigen-presenting cells directly suppresses proliferation and cytokine production of CD4 and CD8 T cells, making it a promising target for cancer immunotherapy.
Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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