Thermo Fisher Scientific BTLA Chimeric Recombinant Rabbit Monoclonal Antibody (HMBT-6B2)
BTLA 단백질을 특이적으로 인식하는 재조합 토끼 단클론 항체로, T세포 및 B세포의 음성 조절 연구에 적합. Western blot, Flow cytometry, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제 및 안정적 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 0.17 ng/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HMBT-6B2 |
| Immunogen | This antibody was raised by immunising Armenian hamsters with mouse BTLA:Fc fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074574 |
Product Specific Information
Specificity: This antibody is specific for B and T lymphocyte attenuator (BTLA), which functions as a negative regulator of T cell activation and proliferation, and attenuates B cell proliferation upon associating with its known ligand, herpes virus entry mediator (HVEM).
Target Information
BTLA (B and T-lymphocyte attenuator) is a member of the co-inhibitory receptors of the CD28 superfamily. It acts as a lymphocyte inhibitory receptor that downregulates immune responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells, with expression decreasing upon T cell activation. It remains expressed on Th1 cells but not Th2 cells. BTLA interacts with HVEM, a TNF receptor superfamily member, forming a key regulatory pathway for lymphocyte activation and immune homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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