Thermo Fisher Scientific TRAIL-R2 (DR5) Chimeric Recombinant Rabbit Monoclonal Antibody (TRA-8)
인간 DR5에 특이적인 재조합 토끼 단클론 항체로, 다양한 면역학적 응용(WB, ICC/IF, Flow, ELISA, Functional Assay)에 사용 가능. HEK293 발현 시스템에서 생산되며, Protein A로 정제된 액상 형태. 연구용으로만 사용.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TRA-8 |
| Immunogen | Fusion protein containing the extracellular portion of human DR5 and Fc portion of human IgG1 (immunized BALB/c mice) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Wet ice |
| RRID | AB_3074568 |
Product Specific Information
- Specificity: The antibody is specific to human DR5 and does not bind other TRAIL receptors, other members of the TNF-receptor superfamily, or the murine homolog of DR5.
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL that mediates TRAIL-induced apoptosis.
It belongs to the TNF-receptor superfamily and transduces apoptosis signals upon activation by TNFSF10/TRAIL/APO-2L.
FADD, a death domain-containing adaptor protein, is required for DR5-mediated apoptosis.
Two transcript variants encoding different isoforms and one non-coding transcript are known.
Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is expressed in various cell types, especially in lymphocytes and spleen.
Diseases associated with DR5 dysfunction include squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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