Thermo Fisher Scientific GABBR1 Monoclonal Antibody (N93A/49), PE
GABBR1 단백질을 인식하는 PE-결합 단일클론 항체로, Western blot 및 면역세포염색에 사용 가능. 인간, 생쥐, 랫트 반응성. 단백질 G 정제, 보존제 무첨가, 4°C 보관. GABA 수용체 연구용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N93A/49 |
| Immunogen | Fusion protein amino acids 873–977 (cytoplasmic C-terminus) of rat GABA(B)R1 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931993 |
Additional Formats
Product Specific Information
- 1 µg/mL of MA5-45539 was sufficient for detection of GABA(B)R1 in 20 µg of rat brain membrane lysate by colorimetric immunoblot using goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 115 kDa.
- No cross-reactivity against GABA(B)R2.
- This antibody was formerly sold as clone S93A-49.
Target Information
GABA(B) receptor 1 (GABBR1) is a receptor for GABA. Its activity is mediated by G-proteins that:
- Inhibit adenylyl cyclase activity
- Stimulate phospholipase A2
- Activate potassium channels
- Inactivate voltage-dependent calcium channels
- Modulate inositol phospholipid hydrolysis
GABBR1 plays a critical role in fine-tuning inhibitory synaptic transmission.
Presynaptic GABA-B receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, while postsynaptic receptors decrease neuronal excitability by activating inwardly rectifying potassium (Kir) channels.
It is implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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