Thermo Fisher Scientific GABBR1 Monoclonal Antibody (N93A/49), APC
GABBR1 단백질을 인식하는 APC 결합 단클론 항체로 Western blot 및 면역세포염색에 사용 가능. 사람, 마우스, 랫트 반응성. 단클론 N93A/49, 단백질 G 정제. 4°C 보관, 방부제 없음. 연구용 전용.
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Applications
Western Blot (WB)
- Tested dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N93A/49 |
| Immunogen | Fusion protein amino acids 873–977 (cytoplasmic C-terminus) of rat GABA(B)R1 |
| Conjugate | APC (Allophycocyanin) |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931990 |
Additional Formats
- Unconjugated: MA5-27704
- FITC: MA5-45537
- PE: MA5-45539
- PerCP: MA5-45538
- Custom conjugation available upon request
Product Specific Information
- 1 µg/mL of MA5-45536 detects GABA(B)R1 in 20 µg of rat brain membrane lysate by colorimetric immunoblot using goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately 115 kDa.
- No cross-reactivity against GABA(B)R2.
- Formerly sold as clone S93A-49.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis. Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, while postsynaptic GABA-B-R decrease neuronal excitability by activating inwardly rectifying potassium (Kir) channels.
Involved in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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