Thermo Fisher Scientific Phospho-beta Catenin (Ser675) Polyclonal Antibody
Phospho-beta Catenin (Ser675) Polyclonal Antibody는 인산화된 Ser675 위치의 β-Catenin을 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 사용 가능하며, Human, Mouse, Rat 등 다양한 종에서 반응합니다. 고순도 정제된 Rabbit IgG 폴리클로날 항체로 연구용으로 최적화되었습니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CTNNB1 (Accession P35222), corresponding to residues around phosphorylated Ser675 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817239 |
Product Specific Information
This antibody detects endogenous levels of beta Catenin only when phosphorylated at Ser675.
Target Information
Beta-catenin is an adherens junction (AJ) protein essential for epithelial cell layer formation and maintenance by regulating cell growth and cell-cell adhesion. It interacts with E-cadherin and alpha-catenin, linking the cadherin complex to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless, tyrosine kinases, and phosphatases.
Beta-catenin is expressed in various hair follicle cell types and plays a role in tumorigenesis, including pilomatrixoma, medulloblastoma, colorectal and ovarian cancers. In the nucleus, it co-activates Lef/Tcf transcription factors that regulate genes promoting cell proliferation (e.g., cyclin D, c-myc).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-105840_beta_Catenin_P35222-1_Rabbit.svg, PA5-105840_beta_Catenin_P35222-1_Rabbit_PDP.jpeg)
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