Thermo Fisher Scientific PTRF Polyclonal Antibody
Human, Mouse, Rat에서 PTRF 단백질을 검출하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용으로만 사용 가능.
- 카탈로그번호
- PA550170
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human PTRF (amino acids 141–167, UniProt ID: Q6NZI2-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635623 |
Product Specific Information
This antibody detects endogenous levels of total PTRF protein.
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts. It regulates rRNA transcription by promoting dissociation of transcription complexes and re-initiation of polymerase I on nascent rRNA transcripts. PTRF localizes to caveolae at the plasma membrane and plays a critical role in caveolae formation and stabilization of caveolins. It translocates from caveolae to the cytoplasm after insulin stimulation and is thought to influence lipid metabolism and insulin-regulated gene expression. Mutations in PTRF are associated with generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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